Barcelona defender Sergino Dest has been ruled out of Sunday’s Clásico with Real Madrid and the USA’s last group in World Cup qualifying.
The 21-year-old suffered a left hamstring injury early in the second half in Barca’s 2-1 Europa League round of 16 win over Galatasaray on Thursday.
Dest suffered a sweep and Barca confirmed on Friday that he would not return to action until after the international break.
As a result, Dest was replaced by Arminia Bielefeld left-back George Bello in the USA squad for the qualifiers against Mexico, Panama and Costa Rica.
Dani Alves is expected to fit in with Dest in a direct swap deal for the La Liga trip to Madrid, but the veteran full-back is not registered for the Europa League.
Barca will face Eintracht Frankfurt in the quarter-finals of this competition, with the first leg scheduled for April 7.
Dest, an Ajax academy product, has played 20 times for Barca in that spell – 10th more than any player – and has been called up 17 times by the United.